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KMID : 0616120070380010084
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 1 p.84 ~ p.89
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(Antioxidant Activity and Neuroprotective Effect of Psoralea corylifolia Linne Extracts)
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Yoon Mi-Young
Kim Ju-Young
Park Hae-Ryong
Lee Bo-Bae
Kim Yong-Sung
Park Eun-Ju
Lee Seung-Cheol
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Abstract
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The present study describes the preliminary evaluation of the antioxidant activities and the neuroprotective effect of methanolic extracts from Psoralea corylifolia Linne (PCE). The antioxidant activities and neuroprotective effect of the PCE were evaluated by total phenolic contents (TPC), DPPH radical scavenging activity (RSA), reducing power (RP), MTT reduction assay, and LDH release assay. TPC, DPPH RSA, and RP of the extract at concentration of 100 {mu}g was 125.93 {mu}g, 63.81%, 0.138, respectively, and those were concentration dependent. The treatment of PC12 and N18-RE-105 cells with various PCE concentrations under H_2O_2 resulted in the induction of protective effect in a dose-dependent manner, as determined by the results of an MTT reduction assay and LDH release assay. Therefore, these results suggest that PCE could be a new potential candidate as an antioxidant against neuronal diseases.
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KEYWORD
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Psoralea corylifolia Linne, antioxidant activity, neuroprotective, PC12 cells, N18-RE-105 cells
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